Tegretol CR 400mg
Original price was: ₨ 5,500.₨ 5,250Current price is: ₨ 5,250.
Brand Name: Novartis
Chemical Name: Carbamazepine
Dosage Strength: 400mg controlled-release tablet (brown-orange, oval, divisible)
Rx/OTC: Prescription only (Rx)
Tegretol CR 400mg is a controlled-release tablet used to control partial and tonic-clonic seizures, ease the sharp nerve pain of trigeminal neuralgia, and stabilise mood in bipolar disorder. The slow-release design gives steadier drug levels with simple twice-daily dosing. It should never be stopped abruptly, as this can trigger seizures.
Key Benefits of Tegretol CR 400mg
How It Works
- Carbamazepine stabilizes hyperexcited neuronal membranes.
- Blocks voltage-dependent sodium channels, reducing repetitive neuronal firing.
- Dampens synaptic transmission in the trigeminal nucleus, relieving neuralgic pain.
- The CR formulation provides steadier plasma levels with lower peak fluctuations and twice-daily dosing.
Dosage, Uses & Possible Side Effects
Dosage & Administration:
- Epilepsy: start 100–200mg once or twice daily; titrate gradually to 800–1200mg/day (max 1600–2000mg).
- Trigeminal neuralgia: 200–400mg/day, increased until pain is controlled (usual 400–800mg/day).
- Swallow whole or split along the score line with water; do not chew. Take before, during, or between meals.
- Plasma levels are typically targeted at 4–12 mcg/mL.
Uses:
- Generalized tonic-clonic and partial (focal) seizures in adults and children.
- Paroxysmal pain of trigeminal neuralgia and glossopharyngeal neuralgia.
- Prophylaxis of manic-depressive (bipolar) psychosis in patients unresponsive to lithium.
- Not typically effective for absence (petit mal) or myoclonic seizures.
Possible Side Effects:
- Common: dizziness, drowsiness, ataxia, nausea, dry mouth.
- Serious: blood dyscrasias (aplastic anemia, agranulocytosis), severe skin reactions (Stevens-Johnson syndrome, toxic epidermal necrolysis), hepatotoxicity, hyponatremia.
- Risk of teratogenicity (including spina bifida) when used in pregnancy.
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Frequently Asked Questions
Yes. Carbamazepine can reduce the effectiveness of hormonal contraceptives alternative or additional contraception may be needed.
No. It increases carbamazepine levels and should be avoided during treatment.
Tegretol CR 400mg price in Pakistan at the medicine store is ₨ 5,250.
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