Advagraf 1mg
Original price was: ₨ 13,500.₨ 13,000Current price is: ₨ 13,000.
Brand Name: Astellas Pharma
Chemical Name: Tacrolimus
Dosage Strength: 1mg prolonged-release hard capsule
Rx/OTC: Prescription only (Rx)
Advagraf 1mg is a once-daily prolonged-release immunosuppressant used to prevent and treat rejection in adults who have had a kidney or liver transplant. By calming the immune system’s T-cells, it helps the body accept the new organ. It must be taken on an empty stomach at the same time each day, and grapefruit must be avoided.
Key Benefits of Advagraf 1mg
How It Works
- Tacrolimus is a calcineurin inhibitor that binds to FKBP-12 inside lymphocytes.
- The complex inhibits calcineurin, blocking transcription of IL-2 and other cytokines needed for T-cell activation.
- The prolonged-release formulation provides 24-hour drug exposure with once-daily dosing.
Dosage, Uses & Possible Side Effects
Dosage & Administration:
- Kidney transplant: 0.20–0.30 mg/kg/day starting within 24 hours after surgery.
- Liver transplant: 0.10–0.20 mg/kg/day, started 12–18 hours post-transplant.
- Once-daily dosing in the morning, on an empty stomach (1 hour before or 2–3 hours after a meal).
- Doses are adjusted based on whole-blood trough levels.
Uses:
- Prophylaxis of transplant rejection in adult kidney or liver allograft recipients.
- Treatment of allograft rejection resistant to other immunosuppressants in adults.
Possible Side Effects:
- Common: tremor, headache, insomnia, hypertension, hyperglycaemia, hyperkalaemia, kidney impairment.
- Serious: nephrotoxicity, neurotoxicity (PRES, seizures), increased risk of serious infections, post-transplant diabetes mellitus, malignancy (lymphoma, skin cancer).
- Boxed warning: increased risk of malignancy and serious infections; should be prescribed only by physicians experienced in immunosuppressive therapy.
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Frequently Asked Questions
Food, especially high-fat meals, reduces absorption and lowers blood levels of tacrolimus.
Conversion is possible under close supervision (usually 1:1 mg total daily dose), with trough monitoring during the switch.
Avoid grapefruit and grapefruit juice; they inhibit CYP3A4 and can dangerously raise tacrolimus levels.
Through 24-hour whole-blood trough levels, kidney function, blood pressure, glucose, and potassium tests.
Advagraf 1mg price in Pakistan at Medicine Store is ₨. 13,000.
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