Nexavar 200mg
Original price was: ₨ 285,000.₨ 275,000Current price is: ₨ 275,000.
Brand Name: Bayer HealthCare Pharmaceuticals
Chemical Name: Sorafenib Tosylate
Dosage Strength: 200mg film-coated tablets (60 tablets per bottle)
Rx / OTC: Rx
Nexavar 200mg by Bayer HealthCare contains sorafenib, an oral multikinase inhibitor used to treat advanced liver cancer (HCC), kidney cancer (RCC), and radioactive iodine-refractory differentiated thyroid cancer. It works by blocking both tumour cell growth signals (RAF kinase) and tumour blood vessel formation (VEGFR, PDGFR), attacking cancer on two fronts at once. The standard dose is 400mg twice daily on an empty stomach, since food reduces absorption by around 30%. As the first systemic therapy proven to extend survival in advanced HCC, Nexavar remains a key targeted oncology option.
Key Benefits of Nexavar 200mg
How It Works
- Sorafenib is an oral multikinase inhibitor, a single molecule that blocks several signalling pathways cancer cells rely on.
- It inhibits RAF kinase (BRAF, CRAF) within tumour cells, disrupting cell proliferation signals.
- It also blocks VEGFR-1, -2, -3, and PDGFR-β on blood vessel cells, cutting off tumour angiogenesis.
- This dual action, stopping tumour growth directly and starving it of blood supply, slows progression of advanced cancers.
Dosage, Uses & Possible Side Effects
Dosage & Administration:
- Standard dose: 400mg (two 200mg tablets) twice daily, total daily dose 800mg.
- Take on an empty stomach, at least 1 hour before or 2 hours after a meal.
- Swallow tablets whole with a glass of water.
- For dermatologic or other toxicities, doses may be reduced to 400mg once daily, 400mg every other day, or temporarily interrupted.
Uses:
- Unresectable hepatocellular carcinoma (HCC) advanced primary liver cancer.
- Advanced renal cell carcinoma (RCC) kidney cancer.
- Locally recurrent or metastatic, progressive differentiated thyroid carcinoma (DTC) that is refractory to radioactive iodine treatment.
- Manufactured by Bayer, each red, round, biconvex film-coated tablet is imprinted with the Bayer cross and “200”.
Possible Side Effects:
- Very common: hand-foot skin reaction, rash, diarrhoea, fatigue, hypertension, and alopecia.
- Serious but less common: bleeding events, cardiac ischaemia, gastrointestinal perforation, and severe dermatologic reactions.
- Blood pressure and liver function should be monitored regularly throughout treatment.
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Frequently Asked Questions
A high-fat meal reduces absorption by approximately 30%. Taking it on an empty stomach ensures consistent drug levels and efficacy.
No. Sorafenib can cause fetal harm. Effective contraception is required during treatment and for at least 2 weeks after the last dose.
Store at 25°C (excursions 15°C–30°C permitted) in the original bottle, protected from moisture.
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