Astonin 0-1mg
Original price was: ₨ 5,550.₨ 5,250Current price is: ₨ 5,250.
Brand Name: Merck (Astonin-H) / Bristol-Myers Squibb (Florinef Acetate, originator)
Chemical Name: Fludrocortisone Acetate
Dosage Strength: 0.1mg scored tablets
Rx / OTC: Rx
Astonin-H 0.1mg by Merck contains fludrocortisone acetate, a synthetic mineralocorticoid used for adrenal insufficiency, Addison’s disease, and salt-losing congenital adrenogenital syndrome. It works by promoting sodium and water retention in the kidneys, restoring blood volume and blood pressure in patients lacking aldosterone. It is taken once daily with food at the same time each day. Often combined with hydrocortisone for complete adrenal hormone replacement.
Key Benefits of Astonin 0.1mg
How It Works
- Fludrocortisone is a synthetic corticosteroid with strong mineralocorticoid activity — roughly 250–800 times that of cortisol.
- It binds to mineralocorticoid receptors in the distal renal tubule, promoting sodium and water reabsorption and potassium excretion.
- This restores salt and water balance in patients whose adrenal glands cannot produce enough aldosterone.
- The resulting increase in circulating blood volume also supports blood pressure.
Dosage, Uses & Possible Side Effects
Dosage & Administration:
- Typical adult dose: 0.1mg once daily, with a range of 0.1mg three times weekly up to 0.2mg daily.
- In Addison’s disease, it is combined with a glucocorticoid such as hydrocortisone for complete adrenal replacement.
- Take at the same time each day with food; do not stop abruptly after prolonged use.
- The dose should be reduced to 0.05mg daily if transient hypertension develops.
Uses:
- Partial replacement therapy in primary and secondary adrenocortical insufficiency, including Addison’s disease.
- Treatment of salt-losing congenital adrenogenital syndrome.
- Off-label management of orthostatic hypotension and postural orthostatic tachycardia syndrome (POTS) by improving sodium retention and blood volume.
- Included on the World Health Organization’s List of Essential Medicines.
Possible Side Effects:
- Common: high blood pressure, fluid retention (oedema), headache, and low potassium (hypokalaemia).
- Long-term use can cause bone thinning, increased infection risk, mood changes, and weight gain.
- Regular monitoring of blood pressure, serum potassium, and signs of fluid overload is essential throughout therapy.
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Frequently Asked Questions
Yes. Both contain 0.1mg of fludrocortisone acetate 0.1mg. Astonin-H is marketed by Merck in Europe; Florinef Acetate was the original US brand from Bristol-Myers Squibb.
No. Abrupt discontinuation can cause acute adrenal insufficiency. Any dose change must be done gradually under medical supervision.
Your doctor may advise adequate salt intake, do not restrict salt unless specifically instructed. Potassium levels should be monitored regularly.
Store at room temperature (20°C–25°C) in a cool, dry place away from excessive heat.
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