Certican Tablet 0.25 Mg 60
Original price was: ₨ 15,000.₨ 14,500Current price is: ₨ 14,500.
Medicine Name: Certican 0.25mg Tablets
Brand Name: Novartis Pharmaceuticals
Chemical Name: Everolimus (40-O-(2-Hydroxyethyl)-Rapamycin)
Dosage Strength: 0.1mg, 0.25mg, 0.5mg, and 0.75mg tablets
Rx / OTC: Rx
Certican Tablet
Certican 0.25 is an advanced immunosuppressant used alongside other medications to prevent kidney and heart transplant rejection. Each Certican tablet works by stopping the proliferation of immune cells, ensuring the body safely accepts the transplanted organ. As a specialized everolimus tablet, it allows doctors to lower the dosage of other potentially toxic anti-rejection drugs. Transplant patients can verify the Certican 0.25 mg price in Pakistan through authorized hospital pharmacies to maintain their daily care.
Key Benefits Of Cialis 5mg Tablets
Allows significant cyclosporine dose reduction, protecting kidney function long-term after transplant.
Dual immunosuppressive and antiproliferative action provides broad transplant protection.
Novartis precision formulation with strict therapeutic drug monitoring for patient safety.
How It Works
- Everolimus inhibits mTOR the mammalian target of rapamycin a central signalling hub that controls T-cell proliferation and vascular smooth muscle growth.
- By blocking mTORC1, Certican interrupts the downstream signals that drive T-lymphocyte multiplication and the rejection response.
- It also inhibits smooth muscle proliferation in blood vessel walls, which contributes to chronic allograft vasculopathy in heart transplant patients.
- The dual action immunosuppressive and antiproliferative provides broad and sustained transplant protection.
Dosage, Uses & Possible Side Effects
Dosage & Administration:
- Take Certican twice daily, exactly 12 hours apart, consistently either always with food or always without food.
- Never alternate between the two; this changes absorption and can destabilise blood levels.
- Grapefruit and grapefruit juice are strictly contraindicated throughout therapy, as they inhibit CYP3A4 and can dramatically raise everolimus blood levels without any dose change.
- Regular trough blood level monitoring targeting 3 to 8 ng/mL is mandatory throughout treatment due to Certican’s narrow therapeutic index.
Uses:
- Protects transplanted kidneys and hearts from rejection while reducing the long-term kidney damage caused by high-dose calcineurin inhibitor therapy.
- Used alongside reduced-dose cyclosporine after kidney and heart transplantation.
- Provides effective rejection protection while significantly lowering the nephrotoxic burden that standard cyclosporine regimens impose over time.
- Manufactured by Novartis Pharmaceuticals.
Possible Side Effects:
- Stomatitis (painful mouth ulcers), impaired wound healing, peripheral oedema, and hyperlipidaemia are the most characteristic side effects.
- Non-infectious pneumonitis, a class-specific mTOR inhibitor effect requires vigilance throughout treatment.
- Report any new respiratory symptoms, including breathlessness or dry cough to your transplant team immediately.
If you experience sudden vision/hearing loss or an erection lasting longer than 4 hours, seek urgent medical help.
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