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Certican 0.75mg
₨ 32,000
Kreon 10000 IU
Original price was: ₨ 14,250.₨ 13,500Current price is: ₨ 13,500.
Certican 0.25mg
₨ 18,000
Brand Name: Novartis Pharmaceuticals
Chemical Name: Everolimus (40-O-(2-Hydroxyethyl)-Rapamycin)
Dosage Strength: 0.1mg, 0.25mg, 0.5mg, and 0.75mg tablets
Rx / OTC: Rx
Description
Certican 0.25mg Tablets
Certican 0.25mg is an advanced immunosuppressant used alongside other medications to prevent kidney and heart transplant rejection. Each Certican tablet works by stopping the proliferation of immune cells, ensuring the body safely accepts the transplanted organ. As a specialized everolimus tablet, it allows doctors to lower the dosage of other potentially toxic anti-rejection drugs. Transplant patients can verify the Certican 0.25 mg price in Pakistan through authorized hospital pharmacies to maintain their daily care.
Key Benefits Of Certican 5mg Tablets
Allows significant cyclosporine dose reduction, protecting kidney function long-term after transplant.
Dual immunosuppressive and antiproliferative action provides broad transplant protection.
Novartis precision formulation with strict therapeutic drug monitoring for patient safety.
How It Works
- Everolimus inhibits mTOR the mammalian target of rapamycin a central signalling hub that controls T-cell proliferation and vascular smooth muscle growth.
- By blocking mTORC1, Certican interrupts the downstream signals that drive T-lymphocyte multiplication and the rejection response.
- It also inhibits smooth muscle proliferation in blood vessel walls, which contributes to chronic allograft vasculopathy in heart transplant patients.
- The dual action immunosuppressive and antiproliferative provides broad and sustained transplant protection.
Dosage, Uses & Possible Side Effects
Dosage & Administration:
- Take Certican twice daily, exactly 12 hours apart, consistently either always with food or always without food.
- Never alternate between the two; this changes absorption and can destabilise blood levels.
- Grapefruit and grapefruit juice are strictly contraindicated throughout therapy, as they inhibit CYP3A4 and can dramatically raise everolimus blood levels without any dose change.
- Regular trough blood level monitoring targeting 3 to 8 ng/mL is mandatory throughout treatment due to Certican’s narrow therapeutic index.
Uses:
- Protects transplanted kidneys and hearts from rejection while reducing the long-term kidney damage caused by high-dose calcineurin inhibitor therapy.
- Used alongside reduced-dose cyclosporine after kidney and heart transplantation.
- Provides effective rejection protection while significantly lowering the nephrotoxic burden that standard cyclosporine regimens impose over time.
- Manufactured by Novartis Pharmaceuticals.
Possible Side Effects:
- Stomatitis (painful mouth ulcers), impaired wound healing, peripheral oedema, and hyperlipidaemia are the most characteristic side effects.
- Non-infectious pneumonitis, a class-specific mTOR inhibitor effect requires vigilance throughout treatment.
- Report any new respiratory symptoms, including breathlessness or dry cough to your transplant team immediately.
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Frequently Asked Questions
How is Certican different from Prograf in transplant care?
Certican is an mTOR inhibitor, while Prograf is a calcineurin inhibitor. Certican is used alongside reduced-dose cyclosporine not tacrolimus in standard kidney and heart transplant protocols.
Why is therapeutic drug monitoring mandatory with Certican?
Certican has a narrow therapeutic window. Levels below 3 ng/mL risk rejection; levels above 8 ng/mL increase toxicity. Regular monitoring keeps levels precisely within the effective and safe range.
What happens if I miss a Certican dose?
Take it as soon as you remember on the same day. If your next dose is approaching, skip the missed one. Never double dose and inform your transplant team at your next monitoring appointment.
How should I store Certican tablets?
Store below 25°C away from moisture and direct light. Keep in the original blister packaging and protect from humidity at all times.
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